Protein Details: Potassium voltage-gated channel subfamily A member 10

Protein ID

ICDB_Pro_1158

Protein Name

Potassium voltage-gated channel subfamily A member 10

Gene Name

KCNA10

Organism

Gallus gallus (Chicken)

Length

516 amino acids

AlphaFoldDB

AF-Q7T199-F1-model_v4.pdb

Function

Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane; the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP (By similarity)

Sequence

MMDVSSWKEMEVALVSFDNADQIVEDPCYSNDLSPASQSRKGHPSCANLLSNWRILINSENANNETIFSRFSAEFSEHLVGERVGMEEGDQRVIINIAGLRFETRLKTLNQFPETLLGDPEKRMRYFDSMRNEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDVFADEITFYELGDEAMDQFREDEGFIKDPETLLPTNDFHRQFWLLFEYPESSSAARGVALVSVLVIVISIIIFCMETLPEFREEREYKSTQELSKNTTDTLLAHSTFTDPFFVIETACIIWFSFELFVRFIVCPSKTEFFKNIMNIIDIVSIIPYFVTLTTELIQQSELNGQQNMSLAILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEVDEPQSHFSSIPDGFWWAVVTMTTVGYGDMCPTTLGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEKQILPGEVERILNSVVTGNDSMESLNKTNGGYPRDKAKK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in brain; cochlear sensory epithelium; cochlear ganglion; tegumentum vasculosum. Detected at low levels in cochlear lagena.

DOI ID

10.1016/j.molbrainres.2003.10.022

RefSeq

NP_989793.1

Feature